Where should I place my ads!?
Believe it or not some of the top sites today are all designed around...you! Research has shown that depending on where you put your ads on
your website the differences in earnings from said ads are significantly less when a site is based solely around looks. Luckly for us, we are not the first ones to use advertisements on our websites and others have done so before us! 
. Here is a heat map of how your basic design should look for optimal performance from your ads. The darker zones indicate where most people look when visiting a website and where you should put your content and your ads respectively.
Google has also has published a list of the highest performing ad sizes:
336×280 large rectangle
300×250 inline rectangle
160×600 wide skyscraper
